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Chicken β-defensin gene cluster
Chicken genome encodes 13 β-defensin (Gal) genes in a single innate-immunity cluster.
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Chicken β-defensin count?
13 Gal genes.
Source: A genome-wide screen identifies a single beta-defensin gene cluster in the chicken: implications for the origin and evolution of mammalian defensins · DOI · quote verified
Novel Gal4–12?
Nine.
Source: A genome-wide screen identifies a single beta-defensin gene cluster in the chicken: implications for the origin and evolution of mammalian defensins · DOI · quote verified
Divergence estimate?
~310 million years ago.
Source: A genome-wide screen identifies a single beta-defensin gene cluster in the chicken: implications for the origin and evolution of mammalian defensins · DOI · quote verified
Gal13 confirmation?
RT-PCR from chicken kidney.
Source: A genome-wide screen identifies a single beta-defensin gene cluster in the chicken: implications for the origin and evolution of mammalian defensins · DOI · quote verified
Peptide class?
Cationic antimicrobial β-defensins.
Source: A genome-wide screen identifies a single beta-defensin gene cluster in the chicken: implications for the origin and evolution of mammalian defensins · DOI · quote verified
Search method?
TBLASTN across chicken databases.
Source: A genome-wide screen identifies a single beta-defensin gene cluster in the chicken: implications for the origin and evolution of mammalian defensins · DOI · quote verified
Gal11 feature?
Two tandem six-cysteine motifs.
Source: A genome-wide screen identifies a single beta-defensin gene cluster in the chicken: implications for the origin and evolution of mammalian defensins · DOI · quote verified
Length range novel?
63–104 amino acids.
Source: A genome-wide screen identifies a single beta-defensin gene cluster in the chicken: implications for the origin and evolution of mammalian defensins · DOI · quote verified
Limit?
Activity of each Gal not fully assayed here.
Source: A genome-wide screen identifies a single beta-defensin gene cluster in the chicken: implications for the origin and evolution of mammalian defensins · DOI · quote verified
Takeaway?
Birds keep a compact β-defensin innate cluster.
Source: A genome-wide screen identifies a single beta-defensin gene cluster in the chicken: implications for the origin and evolution of mammalian defensins · DOI · quote verified