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FLI1 circRNA FECR1 drives metastasis
Exonic circular RNA FECR1 binds the FLI1 promoter and epigenetically activates FLI1 in breast cancer.
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FECR1 identity?
FLI1 exonic circular RNA.
Source: A novel FLI1 exonic circular RNA promotes metastasis in breast cancer by coordinately regulating TET1 and DNMT1 · DOI · quote verified
FECR1 action?
Epigenetically activates FLI1.
Source: A novel FLI1 exonic circular RNA promotes metastasis in breast cancer by coordinately regulating TET1 and DNMT1 · DOI · quote verified
Discovery method?
CasIP at FLI1 promoter.
Source: A novel FLI1 exonic circular RNA promotes metastasis in breast cancer by coordinately regulating TET1 and DNMT1 · DOI · quote verified
Cell line?
MDA-MB231.
Source: A novel FLI1 exonic circular RNA promotes metastasis in breast cancer by coordinately regulating TET1 and DNMT1 · DOI · quote verified
FLI1 in tumors?
Higher vs adjacent normal.
Source: A novel FLI1 exonic circular RNA promotes metastasis in breast cancer by coordinately regulating TET1 and DNMT1 · DOI · quote verified
Partners?
Coordinates TET1 and DNMT1.
Source: A novel FLI1 exonic circular RNA promotes metastasis in breast cancer by coordinately regulating TET1 and DNMT1 · DOI · quote verified
Phenotype assay?
Overexpression tests invasion.
Source: A novel FLI1 exonic circular RNA promotes metastasis in breast cancer by coordinately regulating TET1 and DNMT1 · DOI · quote verified
Fixation?
1% formaldehyde for CasIP.
Source: A novel FLI1 exonic circular RNA promotes metastasis in breast cancer by coordinately regulating TET1 and DNMT1 · DOI · quote verified
Limit?
Mechanistic cancer cell work ≠ therapy trial.
Source: A novel FLI1 exonic circular RNA promotes metastasis in breast cancer by coordinately regulating TET1 and DNMT1 · DOI · quote verified
Takeaway?
circRNA can epigenetically lock on an oncogene.
Source: A novel FLI1 exonic circular RNA promotes metastasis in breast cancer by coordinately regulating TET1 and DNMT1 · DOI · quote verified