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Selective bacterial BSH shifts host metabolism
Bacteroides bile salt hydrolase BT2086 selectively deconjugates bile acids and alters host metabolism.
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Key enzyme gene?
BT2086.
Source: A selective gut bacterial bile salt hydrolase alters host metabolism · DOI · quote verified
KO effect?
Lost bile-acid deconjugation.
Source: A selective gut bacterial bile salt hydrolase alters host metabolism · DOI · quote verified
Screen size?
Twenty Bacteroidetes strains.
Source: A selective gut bacterial bile salt hydrolase alters host metabolism · DOI · quote verified
Selectivity?
Some prefer steroid core patterns.
Source: A selective gut bacterial bile salt hydrolase alters host metabolism · DOI · quote verified
Assay timing?
Steady state by 48 hr.
Source: A selective gut bacterial bile salt hydrolase alters host metabolism · DOI · quote verified
Host model?
Gnotobiotic/monocolonized mice.
Source: A selective gut bacterial bile salt hydrolase alters host metabolism · DOI · quote verified
Phyla?
Bacteroidetes and Firmicutes harbor BSH.
Source: A selective gut bacterial bile salt hydrolase alters host metabolism · DOI · quote verified
Complementation?
BT2086 restores activity.
Source: A selective gut bacterial bile salt hydrolase alters host metabolism · DOI · quote verified
Limit?
Mouse gnotobiology ≠ human diet trials.
Source: A selective gut bacterial bile salt hydrolase alters host metabolism · DOI · quote verified
Takeaway?
One microbial hydrolase can rewire host metabolism.
Source: A selective gut bacterial bile salt hydrolase alters host metabolism · DOI · quote verified