ALICE pillbox app RCT

A Spanish tablet pillbox app improved self-reported adherence and reduced missed doses over 3 months in older adults on multiple medicines.

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What was ALICE designed to do?

Increase adherence and safer medication use via a Spanish tablet self-management app.

How were groups defined?

Control did not use ALICE; experimental used it for 3 months.

Key inclusion criteria?

Multimorbid polypharmacy patients >65, Barthel >60, home medication self-management.

Sample analyzed?

99 patients (48 control, 51 experimental).

How much did adherence scores change?

Increased by 28.3%.

What happened to missed doses?

Fell by 27.3%.

Error reduction among prior error-makers?

Medication errors fell 41.2% versus before the study.

Did clinical status improve?

ALICE did not improve clinical status in 3 months.

How polypharmacy-heavy was the sample?

73% took more than 5 drug types per day.

How was the app co-designed?

Suggestions from 23 patients in nominal groups and 7 professionals in a focus group.