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PrEP adherence in Partners PrEP
In a Partners PrEP adherence substudy, median pill-count and MEMS adherence exceeded 97%, and counseling restored most low adherers to ≥80%.
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Parent trial context?
Partners PrEP phase III RCT of daily oral TDF and FTC/TDF vs placebo in serodiscordant couples.
Source: Adherence to antiretroviral prophylaxis for HIV prevention: a substudy cohort within a clinical trial of serodiscordant couples in East Africa · DOI · quote verified
Substudy size?
1,147 enrolled (66% of participants at three sites).
Source: Adherence to antiretroviral prophylaxis for HIV prevention: a substudy cohort within a clinical trial of serodiscordant couples in East Africa · DOI · quote verified
Objective measures used?
Unannounced pill counts (UPC) and MEMS caps.
Source: Adherence to antiretroviral prophylaxis for HIV prevention: a substudy cohort within a clinical trial of serodiscordant couples in East Africa · DOI · quote verified
Median adherence?
99.1% UPC and 97.2% MEMS.
Source: Adherence to antiretroviral prophylaxis for HIV prevention: a substudy cohort within a clinical trial of serodiscordant couples in East Africa · DOI · quote verified
Low adherence definition?
<80% adherence in a quarter triggered intervention.
Source: Adherence to antiretroviral prophylaxis for HIV prevention: a substudy cohort within a clinical trial of serodiscordant couples in East Africa · DOI · quote verified
Counseling response?
UPC improved to ≥80% in 92% of triggered participants receiving sessions.
Source: Adherence to antiretroviral prophylaxis for HIV prevention: a substudy cohort within a clinical trial of serodiscordant couples in East Africa · DOI · quote verified
Demographics?
53% male; median age 34; 35% on placebo; 99% married.
Source: Adherence to antiretroviral prophylaxis for HIV prevention: a substudy cohort within a clinical trial of serodiscordant couples in East Africa · DOI · quote verified
Retention in parent follow-up?
97% at 1 year and 96% at 2 years.
Source: Adherence to antiretroviral prophylaxis for HIV prevention: a substudy cohort within a clinical trial of serodiscordant couples in East Africa · DOI · quote verified
Efficacy context?
DSMB reported 67% efficacy TDF and 75% FTC/TDF for HIV protection.
Source: Adherence to antiretroviral prophylaxis for HIV prevention: a substudy cohort within a clinical trial of serodiscordant couples in East Africa · DOI · quote verified
Why adherence matters here?
High adherence is needed for measured efficacy to approach biologic efficacy.
Source: Adherence to antiretroviral prophylaxis for HIV prevention: a substudy cohort within a clinical trial of serodiscordant couples in East Africa · DOI · quote verified