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Three CpGs track blood aging
Age-related blood DNA methylation at a few CpGs predicts chronological age with ~3.3-year MAD.
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Profiles combined?
575.
Source: Aging of blood can be tracked by DNA methylation changes at just three CpG sites · DOI · quote verified
AR-CpGs?
102 (58 hypo, 44 hyper).
Source: Aging of blood can be tracked by DNA methylation changes at just three CpG sites · DOI · quote verified
Three-site MAD?
3.34 years.
Source: Aging of blood can be tracked by DNA methylation changes at just three CpG sites · DOI · quote verified
Age span?
0 to 78 years.
Source: Aging of blood can be tracked by DNA methylation changes at just three CpG sites · DOI · quote verified
Platform?
HumanMethylation27 BeadChip.
Source: Aging of blood can be tracked by DNA methylation changes at just three CpG sites · DOI · quote verified
Minimal assay?
Three CpGs by bisulfite sequencing.
Source: Aging of blood can be tracked by DNA methylation changes at just three CpG sites · DOI · quote verified
R² of model?
0.98.
Source: Aging of blood can be tracked by DNA methylation changes at just three CpG sites · DOI · quote verified
Hypo AR-CpG theme?
Hematopoietic regulation genes.
Source: Aging of blood can be tracked by DNA methylation changes at just three CpG sites · DOI · quote verified
Limit?
Prediction ≠ causal aging mechanism.
Source: Aging of blood can be tracked by DNA methylation changes at just three CpG sites · DOI · quote verified
Takeaway?
Few CpGs chronometer blood age.
Source: Aging of blood can be tracked by DNA methylation changes at just three CpG sites · DOI · quote verified