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Traffic NOx linked to cervical and brain cancer risk
In 54,304 Danish adults, long-term traffic-related NOx at home was associated with cervical and brain cancer, with a weaker liver-cancer traffic signal.
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Which cohort supplied the Danish traffic–cancer analysis?
The Diet, Cancer and Health cohort of 50–64-year-olds in Copenhagen and Aarhus.
Source: Air pollution from traffic and cancer incidence: a Danish cohort study · DOI · quote verified
How many people entered the cancer analyses?
54,304 after exclusions, followed 9.6 years on average.
Source: Air pollution from traffic and cancer incidence: a Danish cohort study · DOI · quote verified
What exposure increment defined the linear IRRs?
Per 100 μg/m³ NOx and per 10^4 vehicle km/day within 200 m.
Source: Air pollution from traffic and cancer incidence: a Danish cohort study · DOI · quote verified
Which cancers remained significant after adjustment?
Cervical cancer, brain cancer, and liver cancer with nearby traffic (not NOx).
Source: Air pollution from traffic and cancer incidence: a Danish cohort study · DOI · quote verified
How large was the brain-cancer contrast near a busy street?
Almost doubled for people living close to a high-traffic street.
Source: Air pollution from traffic and cancer incidence: a Danish cohort study · DOI · quote verified
What was typical residential NOx?
Median 21.9 μg/m³ (13.8–347).
Source: Air pollution from traffic and cancer incidence: a Danish cohort study · DOI · quote verified
From when were address histories used?
1 January 1971 until diagnosis or censoring.
Source: Air pollution from traffic and cancer incidence: a Danish cohort study · DOI · quote verified
Why is the cervical finding hypothesis-generating?
HPV infection was unmeasured, and 20 cancer sites were screened.
Source: Air pollution from traffic and cancer incidence: a Danish cohort study · DOI · quote verified
Did confounder adjustment change smoking-related cancers?
Yes; IRRs fell for esophagus, bladder, and breast cancer.
Source: Air pollution from traffic and cancer incidence: a Danish cohort study · DOI · quote verified
How well did modeled NOx match a busy Copenhagen street?
r = 0.88 for NOx over 12 years; modeled mean 6% lower than measured.
Source: Air pollution from traffic and cancer incidence: a Danish cohort study · DOI · quote verified
What did the authors conclude overall?
Significant associations with cervical and brain cancer that need replication.
Source: Air pollution from traffic and cancer incidence: a Danish cohort study · DOI · quote verified