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Wine, alcohol, and depression
In PREDIMED adults, low-to-moderate alcohol—especially wine—associated with lower incident depression risk versus abstaining, while heavy drinking looked riskier.
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Sample?
5,505 older Mediterranean adults (2,683 men, 2,822 women).
Source: Alcohol intake, wine consumption and the development of depression: the PREDIMED study · DOI · quote verified
Outcome events?
443 incident depression cases over 23,655 person-years.
Source: Alcohol intake, wine consumption and the development of depression: the PREDIMED study · DOI · quote verified
Significant intake category?
Low-to-moderate >5–15 g/day remained significant (HR 0.72).
Source: Alcohol intake, wine consumption and the development of depression: the PREDIMED study · DOI · quote verified
Authors’ conclusion?
Low-to-moderate alcohol and wine may reduce incident depression; heavy drinkers seem higher risk.
Source: Alcohol intake, wine consumption and the development of depression: the PREDIMED study · DOI · quote verified
Wine’s share of intake?
Wine explained 82% of alcohol intake variability.
Source: Alcohol intake, wine consumption and the development of depression: the PREDIMED study · DOI · quote verified
Parent study aim?
PREDIMED assessed Mediterranean diet for primary CVD prevention.
Source: Alcohol intake, wine consumption and the development of depression: the PREDIMED study · DOI · quote verified
Sex interaction?
No effect modification of alcohol intake by sex (P = 0.45).
Source: Alcohol intake, wine consumption and the development of depression: the PREDIMED study · DOI · quote verified
Reference group?
Abstainers used as reference for hazard ratios.
Source: Alcohol intake, wine consumption and the development of depression: the PREDIMED study · DOI · quote verified
Only-beer drinkers rare?
Only 308 only-beer and 61 only-spirits drinkers.
Source: Alcohol intake, wine consumption and the development of depression: the PREDIMED study · DOI · quote verified
Why caution clinically?
Further cohorts needed; association ≠ prescription to drink for mental health.
Source: Alcohol intake, wine consumption and the development of depression: the PREDIMED study · DOI · quote verified