Flashcard library · Medicine & Health · PaperFren
ANXA1 in breast cancer prognosis
ANXA1-positive breast tumors clustered with poor-prognosis features (high grade, basal/TN, BRCA1/2) and worse outcomes in some high-risk subgroups such as HER2+.
Keep what you just learned
Save these 10 cards to your NoteFren library. Your first review starts right away, and each card links back to the study it came from.
Sample size?
5,752 BCAC patients plus 107 BRCA1/2 familial cases.
Source: Annexin A1 expression in a pooled breast cancer series: association with tumor subtypes and prognosis · DOI · quote verified
Grade association?
High-grade tumors associated with ANXA1 positivity (OR adj 1.59).
Source: Annexin A1 expression in a pooled breast cancer series: association with tumor subtypes and prognosis · DOI · quote verified
Conclusion on phenotype?
ANXA1 associated with poor-prognosis features: high grade, TN, BRCA1/2.
Source: Annexin A1 expression in a pooled breast cancer series: association with tumor subtypes and prognosis · DOI · quote verified
HER2+ survival signal?
ANXA1 overexpression worse 10-year BCSS (HR adj 1.70).
Source: Annexin A1 expression in a pooled breast cancer series: association with tumor subtypes and prognosis · DOI · quote verified
BRCA subset note?
In BRCA1/2 patients, ANXA1 associated with p53 positivity (OR adj 14.97).
Source: Annexin A1 expression in a pooled breast cancer series: association with tumor subtypes and prognosis · DOI · quote verified
Authors’ caution?
Further studies needed on prognostic vs chemotherapy-response prediction roles.
Source: Annexin A1 expression in a pooled breast cancer series: association with tumor subtypes and prognosis · DOI · quote verified
Age 50–69 signal?
Worse BCSS when ANXA1 positive (HR adj 2.02) in ages 50–69.
Source: Annexin A1 expression in a pooled breast cancer series: association with tumor subtypes and prognosis · DOI · quote verified
What is ANXA1 biologically?
Phospholipid-binding protein involved in membrane, apoptosis, and differentiation pathways.
Source: Annexin A1 expression in a pooled breast cancer series: association with tumor subtypes and prognosis · DOI · quote verified
Why study subtypes?
Breast cancer is heterogeneous with differing recurrence risk and therapy response.
Source: Annexin A1 expression in a pooled breast cancer series: association with tumor subtypes and prognosis · DOI · quote verified
Student takeaway?
Tissue biomarkers can mark aggressive subtypes even before therapy decisions are changed.
Source: Annexin A1 expression in a pooled breast cancer series: association with tumor subtypes and prognosis · DOI · quote verified