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PD-1 blockade reactivates TB via TNF
Anti-PD-1 immunotherapy can reactivate tuberculosis through TNF-α dysregulation.
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Human cohort?
35 TB lung-resection patients.
Source: Anti-PD-1 immunotherapy leads to tuberculosis reactivation via dysregulation of TNF-α · DOI · quote verified
Blood matches?
23 patients.
Source: Anti-PD-1 immunotherapy leads to tuberculosis reactivation via dysregulation of TNF-α · DOI · quote verified
Key mediator?
TNF-α.
Source: Anti-PD-1 immunotherapy leads to tuberculosis reactivation via dysregulation of TNF-α · DOI · quote verified
Rescue?
TNF neutralization reverses phenotype.
Source: Anti-PD-1 immunotherapy leads to tuberculosis reactivation via dysregulation of TNF-α · DOI · quote verified
PD-1 locale?
Lung tissue-resident T cells.
Source: Anti-PD-1 immunotherapy leads to tuberculosis reactivation via dysregulation of TNF-α · DOI · quote verified
Therapy context?
Anti-PD-1 immunotherapy.
Source: Anti-PD-1 immunotherapy leads to tuberculosis reactivation via dysregulation of TNF-α · DOI · quote verified
Readout method?
Flow cytometry of lung T cells.
Source: Anti-PD-1 immunotherapy leads to tuberculosis reactivation via dysregulation of TNF-α · DOI · quote verified
CD markers?
CD69/CD103 residency marks.
Source: Anti-PD-1 immunotherapy leads to tuberculosis reactivation via dysregulation of TNF-α · DOI · quote verified
Limit?
Mechanistic/model + observational human tissue.
Source: Anti-PD-1 immunotherapy leads to tuberculosis reactivation via dysregulation of TNF-α · DOI · quote verified
Takeaway?
Checkpoint blockade can unbalance TB control via TNF.
Source: Anti-PD-1 immunotherapy leads to tuberculosis reactivation via dysregulation of TNF-α · DOI · quote verified