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Antidepressant adverse events cohort
In 238,963 adults aged 20–64 with depression, most used antidepressants and several common agents associated with higher fall rates versus non-use.
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Cohort size?
238,963 eligible patients after exclusions.
Source: Antidepressant use and risk of adverse outcomes in people aged 20-64 years: cohort study using a primary care database · DOI · quote verified
Treatment prevalence?
87.7% treated with antidepressants during follow-up.
Source: Antidepressant use and risk of adverse outcomes in people aged 20-64 years: cohort study using a primary care database · DOI · quote verified
Most prescribed agents?
Citalopram (31.5%), fluoxetine (23.9%), amitriptyline (7.3%).
Source: Antidepressant use and risk of adverse outcomes in people aged 20-64 years: cohort study using a primary care database · DOI · quote verified
Falls signal?
8 of 11 common antidepressants associated with increased fall rates vs non-use (P < 0.01).
Source: Antidepressant use and risk of adverse outcomes in people aged 20-64 years: cohort study using a primary care database · DOI · quote verified
Authors’ caution?
Observational design susceptible to residual confounding despite large size.
Source: Antidepressant use and risk of adverse outcomes in people aged 20-64 years: cohort study using a primary care database · DOI · quote verified
Age range?
Adults 20–64 years with depression diagnosis.
Source: Antidepressant use and risk of adverse outcomes in people aged 20-64 years: cohort study using a primary care database · DOI · quote verified
Median treatment duration?
221 days (IQR 79–590).
Source: Antidepressant use and risk of adverse outcomes in people aged 20-64 years: cohort study using a primary care database · DOI · quote verified
Sex mix?
146,028 (61%) women; mean age 39.
Source: Antidepressant use and risk of adverse outcomes in people aged 20-64 years: cohort study using a primary care database · DOI · quote verified
Clinical takeaway?
Consider rare but real adverse effects alongside benefits when choosing antidepressants.
Source: Antidepressant use and risk of adverse outcomes in people aged 20-64 years: cohort study using a primary care database · DOI · quote verified
Follow-up length?
1,307,326 person-years; median 5.2 years per person.
Source: Antidepressant use and risk of adverse outcomes in people aged 20-64 years: cohort study using a primary care database · DOI · quote verified