Flashcard library · Environmental Science · PaperFren
Phthalates track weaker grip in Korean elders
Higher urinary DEHP and MnBP metabolites were inversely associated with handgrip strength in community-dwelling older adults, especially with a high omega-6/omega-3 diet.
Keep what you just learned
Save these 10 cards to your NoteFren library. Your first review starts right away, and each card links back to the study it came from.
Which cohort was studied?
KEEP II, a 2012–2015 repeated-measures panel of Korean elders.
Source: Association between phthalate exposure and lower handgrip strength in an elderly population: a repeated-measures study · DOI · quote verified
How many elders were recruited?
1,253 noninstitutionalized volunteers in Seoul and Asan.
Source: Association between phthalate exposure and lower handgrip strength in an elderly population: a repeated-measures study · DOI · quote verified
What was the main finding for grip strength?
Urinary MEOHP, MEHHP, and MnBP were inversely associated with right and left handgrip.
Source: Association between phthalate exposure and lower handgrip strength in an elderly population: a repeated-measures study · DOI · quote verified
What were enrollment geometric means?
MEOHP 15.48, MEHHP 21.11, and MnBP 28.23 μg/L.
Source: Association between phthalate exposure and lower handgrip strength in an elderly population: a repeated-measures study · DOI · quote verified
How was grip measured?
Tanita dynamometer, two attempts per hand, average of right and left.
Source: Association between phthalate exposure and lower handgrip strength in an elderly population: a repeated-measures study · DOI · quote verified
Did diet modify the association?
Yes, at an omega-6/omega-3 ratio of 8.81 (75th percentile).
Source: Association between phthalate exposure and lower handgrip strength in an elderly population: a repeated-measures study · DOI · quote verified
Was there a sex difference?
No; all sex-interaction p-values > 0.10.
Source: Association between phthalate exposure and lower handgrip strength in an elderly population: a repeated-measures study · DOI · quote verified
What parent compound do MEOHP and MEHHP share?
DEHP; they were also summed as ΣDEHP.
Source: Association between phthalate exposure and lower handgrip strength in an elderly population: a repeated-measures study · DOI · quote verified
What confounding concern do the authors raise?
Medical devices and pharmaceutical coatings that both contain phthalates and relate to frailty.
Source: Association between phthalate exposure and lower handgrip strength in an elderly population: a repeated-measures study · DOI · quote verified
Who is underrepresented, limiting generalizability?
People with low physical function and more disease; the panel is mostly healthy older women.
Source: Association between phthalate exposure and lower handgrip strength in an elderly population: a repeated-measures study · DOI · quote verified