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PFAS in Ronneby water tracks higher cholesterol

Swedish adults on PFAS-contaminated water had 7–9% higher total cholesterol and LDL, with high odds of cholesterol >6.2 mmol/L as PFOS/PFHxS rose.

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Where did the PFAS exposure come from?

One of two Ronneby waterworks was found contaminated in 2013.

How many adults entered the lipid analysis?

1,945 aged 20–60 from 2,791 open-sampling volunteers.

Which PFAS dominated exposed sera?

PFOS (median 157 ng/ml) and PFHxS (median 136 ng/ml).

How much higher were cholesterol and LDL in the contaminated area?

7–9% versus the control area.

What was the odds ratio for high cholesterol per ln-PFAS?

About 1.3 per unit increase in ln-PFAS.

How was high cholesterol defined?

Serum total cholesterol >6.2 mmol/L.

Who were the controls?

Karlshamn residents never exposed to the contaminated water at home (n=130).

How large was the recently exposed Ronneby group?

1,160 people living in the contaminated area any time in 2005–2013.

Why can’t PFOS and PFHxS effects be separated?

Spearman correlation 0.75 in controls and 0.9 in the contaminated group.

Why do the authors say a 5% cholesterol rise matters?

Even in the normal range it increases ischemic heart-disease risk by at least 5%.