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B. dorei rises before T1D autoimmunity
Bacteroides dorei dominates the gut microbiome before autoimmunity in high-risk Finnish children.
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Samples?
947 stools.
Source: Bacteroides dorei dominates gut microbiome prior to autoimmunity in Finnish children at high risk for type 1 diabetes · DOI · quote verified
Children?
76.
Source: Bacteroides dorei dominates gut microbiome prior to autoimmunity in Finnish children at high risk for type 1 diabetes · DOI · quote verified
Cases?
29 seroconverters.
Source: Bacteroides dorei dominates gut microbiome prior to autoimmunity in Finnish children at high risk for type 1 diabetes · DOI · quote verified
Controls?
47.
Source: Bacteroides dorei dominates gut microbiome prior to autoimmunity in Finnish children at high risk for type 1 diabetes · DOI · quote verified
Key microbe?
Bacteroides dorei.
Source: Bacteroides dorei dominates gut microbiome prior to autoimmunity in Finnish children at high risk for type 1 diabetes · DOI · quote verified
Mean seroconversion age?
16.8 months.
Source: Bacteroides dorei dominates gut microbiome prior to autoimmunity in Finnish children at high risk for type 1 diabetes · DOI · quote verified
Genetic risk control?
HLA-DQB1 risk genotypes.
Source: Bacteroides dorei dominates gut microbiome prior to autoimmunity in Finnish children at high risk for type 1 diabetes · DOI · quote verified
Timing claim?
Dominance prior to autoimmunity.
Source: Bacteroides dorei dominates gut microbiome prior to autoimmunity in Finnish children at high risk for type 1 diabetes · DOI · quote verified
Limit?
Association, not proven causation.
Source: Bacteroides dorei dominates gut microbiome prior to autoimmunity in Finnish children at high risk for type 1 diabetes · DOI · quote verified
Takeaway?
Microbiome shifts can precede autoimmunity.
Source: Bacteroides dorei dominates gut microbiome prior to autoimmunity in Finnish children at high risk for type 1 diabetes · DOI · quote verified