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FeMn single-atom nanozyme dual-readout HER2 test
An etched FeMn–N–C nanozyme boosts peroxidase-like activity 2.03-fold and reports HER2 by electrochemistry and 808 nm photothermal readout.
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What nanozyme is the dual-readout probe?
FeMn-NCetch/SAC, a bimetallic single-atom M–N–C peroxidase mimic.
Source: Bimetallic Single-Atom Nanozyme-Based Electrochemical-Photothermal Dual-Function Portable Immunoassay with Smartphone Imaging · DOI · quote verified
How much did bimetallic etching boost POD activity?
2.03 times versus Fe-NC/SAC.
Source: Bimetallic Single-Atom Nanozyme-Based Electrochemical-Photothermal Dual-Function Portable Immunoassay with Smartphone Imaging · DOI · quote verified
What two independent signals are used?
Electrochemistry plus 808 nm photothermal heating.
Source: Bimetallic Single-Atom Nanozyme-Based Electrochemical-Photothermal Dual-Function Portable Immunoassay with Smartphone Imaging · DOI · quote verified
How is POD activity assayed?
TMB/H2O2 in acetate pH 4, absorbance at 652 nm after 6 min.
Source: Bimetallic Single-Atom Nanozyme-Based Electrochemical-Photothermal Dual-Function Portable Immunoassay with Smartphone Imaging · DOI · quote verified
What pyrolysis temperature makes N-doped carbon?
750 °C for 2 h in argon (5 °C/min) from ZnO@ZIF-8 nanorods.
Source: Bimetallic Single-Atom Nanozyme-Based Electrochemical-Photothermal Dual-Function Portable Immunoassay with Smartphone Imaging · DOI · quote verified
How was serum accuracy checked?
Five hospital sera versus commercial HER2 ELISA; texp < 2.78.
Source: Bimetallic Single-Atom Nanozyme-Based Electrochemical-Photothermal Dual-Function Portable Immunoassay with Smartphone Imaging · DOI · quote verified
What H2O2 source is used in the bioassay concept?
H2O2 from glucose oxidase breakdown of glucose.
Source: Bimetallic Single-Atom Nanozyme-Based Electrochemical-Photothermal Dual-Function Portable Immunoassay with Smartphone Imaging · DOI · quote verified
Why etch the carbon?
Defective sites allow bimetallic atom doping and higher POD-like activity.
Source: Bimetallic Single-Atom Nanozyme-Based Electrochemical-Photothermal Dual-Function Portable Immunoassay with Smartphone Imaging · DOI · quote verified
What Fe/Mn salt amounts are used for the bimetallic SAC?
90 mg FeCl3·6H2O and 66 mg MnCl2·4H2O.
Source: Bimetallic Single-Atom Nanozyme-Based Electrochemical-Photothermal Dual-Function Portable Immunoassay with Smartphone Imaging · DOI · quote verified
What sandwich incubation is used for HER2?
Standards/samples on mAb1 plates, 37 °C for 60 min.
Source: Bimetallic Single-Atom Nanozyme-Based Electrochemical-Photothermal Dual-Function Portable Immunoassay with Smartphone Imaging · DOI · quote verified
What prevalence of HER2-positive breast cancer is cited?
About 20–30%.
Source: Bimetallic Single-Atom Nanozyme-Based Electrochemical-Photothermal Dual-Function Portable Immunoassay with Smartphone Imaging · DOI · quote verified