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Serum PFAS mixes reveal seafood vs product exposure

Long-chain PFCAs mark seafood/whale diets, while PFHxS and N-EtFOSAA mark carpets and consumer products in children.

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What question did the PFAS-profile study ask?

Whether the mix of PFASs in serum can identify major exposure sources.

Who had PFOS-dominated profiles?

Faroese whaling men, with PFOS almost 80% of summed PFASs.

How did PCA separate groups?

PC1 (51%) split whalers from children and women; PC2 (17%) scored high in children.

Which compounds were elevated in 7-year-old children?

PFHxS and N-EtFOSAA versus whalers and women.

How did hair mercury relate to PFAS?

Significant Spearman correlations (0.35–0.61) with PFHpS, PFDA, PFOS, and PFUnDA.

What did carpets do in NHANES?

Associated with 37.2% higher PFHxS, 17.2% N-MeFOSAA, and 12.2% PFOS.

Which PFAS tracked seafood in NHANES and CHirP?

PFNA was associated with increased seafood consumption in both.

How much NHANES PFAS variance did models explain?

Only 9–25% for six PFASs in 2005–06.

How many PFASs were measured in Faroese sera?

Fifteen compounds, all frequently detected in whalers (60–100%).

What do the authors recommend for routine biomonitoring?

Report more than the usual five or six PFASs so source inferences are possible.