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LN DCs shelter antibiotic-tolerant Salmonella
Slow-growing Salmonella in cecum lymph-node dendritic cells survive ciprofloxacin therapy.
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Lumen clearance?
Within 3 h of ciprofloxacin.
Source: Cecum lymph node dendritic cells harbor slow-growing bacteria phenotypically tolerant to antibiotic treatment · DOI · quote verified
Persisters left?
50–1,000 up to 10 days.
Source: Cecum lymph node dendritic cells harbor slow-growing bacteria phenotypically tolerant to antibiotic treatment · DOI · quote verified
Early cLN kill?
10-fold in first 2 h.
Source: Cecum lymph node dendritic cells harbor slow-growing bacteria phenotypically tolerant to antibiotic treatment · DOI · quote verified
Niche?
Cecum lymph-node dendritic cells.
Source: Cecum lymph node dendritic cells harbor slow-growing bacteria phenotypically tolerant to antibiotic treatment · DOI · quote verified
Drug?
Ciprofloxacin.
Source: Cecum lymph node dendritic cells harbor slow-growing bacteria phenotypically tolerant to antibiotic treatment · DOI · quote verified
Dose?
5×10^7 cfu gavage.
Source: Cecum lymph node dendritic cells harbor slow-growing bacteria phenotypically tolerant to antibiotic treatment · DOI · quote verified
Mouse?
C57BL/6 susceptible model.
Source: Cecum lymph node dendritic cells harbor slow-growing bacteria phenotypically tolerant to antibiotic treatment · DOI · quote verified
Concept?
Phenotypic tolerance/persistence.
Source: Cecum lymph node dendritic cells harbor slow-growing bacteria phenotypically tolerant to antibiotic treatment · DOI · quote verified
Limit?
Mouse Salmonella model.
Source: Cecum lymph node dendritic cells harbor slow-growing bacteria phenotypically tolerant to antibiotic treatment · DOI · quote verified
Takeaway?
Immune niches can protect tolerant bacteria.
Source: Cecum lymph node dendritic cells harbor slow-growing bacteria phenotypically tolerant to antibiotic treatment · DOI · quote verified