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pH-swelling chitosan–xanthan gels that hold acyclovir
Free-radical chitosan/xanthan/AMPS networks barely swell in acid but open in intestine-like pH, trapping up to 90.64% acyclovir.
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How is the hydrogel network made?
Free-radical polymerization of chitosan and xanthan gum with AMPS.
Source: Chitosan/Xanthan Gum Based Hydrogels as Potential Carrier for an Antiviral Drug: Fabrication, Characterization, and Safety Evaluation · DOI · quote verified
How was the network confirmed?
FTIR showed successful formation; SEM showed a porous structure.
Source: Chitosan/Xanthan Gum Based Hydrogels as Potential Carrier for an Antiviral Drug: Fabrication, Characterization, and Safety Evaluation · DOI · quote verified
Where does the gel swell?
Very low in simulated gastric fluid; much higher in simulated intestinal fluid.
Source: Chitosan/Xanthan Gum Based Hydrogels as Potential Carrier for an Antiviral Drug: Fabrication, Characterization, and Safety Evaluation · DOI · quote verified
What %DEE and pH 7.4 release does FCX6 show?
90.64% entrapment and 87.57% drug released.
Source: Chitosan/Xanthan Gum Based Hydrogels as Potential Carrier for an Antiviral Drug: Fabrication, Characterization, and Safety Evaluation · DOI · quote verified
What is the minimum DEE among formulations?
FCX8 at 76.83%.
Source: Chitosan/Xanthan Gum Based Hydrogels as Potential Carrier for an Antiviral Drug: Fabrication, Characterization, and Safety Evaluation · DOI · quote verified
How does chitosan loading change swelling?
Swelling increases from 4 to 8 g CS then falls from 8 to 12 g.
Source: Chitosan/Xanthan Gum Based Hydrogels as Potential Carrier for an Antiviral Drug: Fabrication, Characterization, and Safety Evaluation · DOI · quote verified
What XG level swells most?
3 g xanthan vs 1 or 2 g.
Source: Chitosan/Xanthan Gum Based Hydrogels as Potential Carrier for an Antiviral Drug: Fabrication, Characterization, and Safety Evaluation · DOI · quote verified
How does AMPS concentration affect swelling?
Swelling index increases sharply from 15 to 35 g AMPS.
Source: Chitosan/Xanthan Gum Based Hydrogels as Potential Carrier for an Antiviral Drug: Fabrication, Characterization, and Safety Evaluation · DOI · quote verified
What MBA trend is reported?
Highest swelling at 0.6 g MBA vs 1.2 or 1.8 g.
Source: Chitosan/Xanthan Gum Based Hydrogels as Potential Carrier for an Antiviral Drug: Fabrication, Characterization, and Safety Evaluation · DOI · quote verified
How pH-dependent is ACV release over 24 h?
Very little at pH 1.2; significantly more at pH 7.4.
Source: Chitosan/Xanthan Gum Based Hydrogels as Potential Carrier for an Antiviral Drug: Fabrication, Characterization, and Safety Evaluation · DOI · quote verified
How is drug loaded?
Dried hydrogels immersed in 1% ACV at 25 °C.
Source: Chitosan/Xanthan Gum Based Hydrogels as Potential Carrier for an Antiviral Drug: Fabrication, Characterization, and Safety Evaluation · DOI · quote verified