Shared class A GPCR activation path

Class A GPCRs share a conserved residue-contact rearrangement pathway from ligand pocket to G-protein site.

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Pathway contacts?

34 residue pairs.

Inactive structures?

142.

Active structures?

27.

Metric?

RRCS / ΔRRCS contact scores.

Layer 1 idea?

Transmission switch + Na⁺ pocket.

Stats?

p<0.001 active vs inactive.

Receptor class?

Class A GPCRs.

Endpoint?

G-protein-competent cytosolic interface.

Limit?

Shared core ≠ identical ligands.

Takeaway?

Diverse agonists converge on one allosteric path.