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Muscle ATP defect in diabetes-prone offspring
Lean insulin-resistant offspring of type 2 diabetic parents showed blunted insulin-stimulated muscle ATP synthesis versus matched controls.
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Who were the IR offspring participants?
Four male and three female lean adults with multi-relative type 2 diabetes family history.
Source: Decreased insulin-stimulated ATP synthesis and phosphate transport in muscle of insulin-resistant offspring of type 2 diabetic parents · DOI · quote verified
How much did insulin raise ATP flux in controls?
About 90% over basal rates.
Source: Decreased insulin-stimulated ATP synthesis and phosphate transport in muscle of insulin-resistant offspring of type 2 diabetic parents · DOI · quote verified
What happened to ATP flux in IR offspring?
Only about a 5% rise despite similar insulin increase.
Source: Decreased insulin-stimulated ATP synthesis and phosphate transport in muscle of insulin-resistant offspring of type 2 diabetic parents · DOI · quote verified
How did authors interpret the ATP defect?
As a very early defect in insulin resistance and type 2 diabetes pathogenesis.
Source: Decreased insulin-stimulated ATP synthesis and phosphate transport in muscle of insulin-resistant offspring of type 2 diabetic parents · DOI · quote verified
What broader conclusion about mitochondria was drawn?
Further evidence of skeletal-muscle mitochondrial dysfunction in IR offspring.
Source: Decreased insulin-stimulated ATP synthesis and phosphate transport in muscle of insulin-resistant offspring of type 2 diabetic parents · DOI · quote verified
What imaging/spectroscopy method assessed Pi transport?
31P MRS before and during the clamp.
Source: Decreased insulin-stimulated ATP synthesis and phosphate transport in muscle of insulin-resistant offspring of type 2 diabetic parents · DOI · quote verified
Were participants matched on lifestyle factors?
Yes—group matched for age, BMI, and sedentary activity.
Source: Decreased insulin-stimulated ATP synthesis and phosphate transport in muscle of insulin-resistant offspring of type 2 diabetic parents · DOI · quote verified
What disease risk framed the introduction?
Rising global type 2 diabetes burden.
Source: Decreased insulin-stimulated ATP synthesis and phosphate transport in muscle of insulin-resistant offspring of type 2 diabetic parents · DOI · quote verified
What prior mitochondrial finding did they cite?
~30% lower basal ATP synthesis and ~2-fold higher IMCL in IR offspring.
Source: Decreased insulin-stimulated ATP synthesis and phosphate transport in muscle of insulin-resistant offspring of type 2 diabetic parents · DOI · quote verified
What physiologic stimulus was compared?
Insulin stimulation of muscle ATP synthase flux.
Source: Decreased insulin-stimulated ATP synthesis and phosphate transport in muscle of insulin-resistant offspring of type 2 diabetic parents · DOI · quote verified
Were participants medication-taking diabetics?
No—prescreened healthy, lean, no medications.
Source: Decreased insulin-stimulated ATP synthesis and phosphate transport in muscle of insulin-resistant offspring of type 2 diabetic parents · DOI · quote verified