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Al3+ lights up Ag/Au clusters to sense fluoroquinolones
Dithioerythritol Ag/Au nanoclusters aggregate with Al3+ and then report ciprofloxacin, norfloxacin and enrofloxacin by ratiometric fluorescence down to a few nanomolar.
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What sensing scheme is used for fluoroquinolones?
Ratiometric fluorescence from Al3+-triggered AIE of DIT@AgAuNCs.
Source: Dithioerythritol-capped silver/gold nanoclusters for determination of ciprofloxacin, norfloxacin, and enrofloxacin in food and urine samples · DOI · quote verified
How do FQs interact with the Al3+-cluster assembly?
They bind Al3+ via carboxyl and carbonyl groups and turn on their own fluorescence.
Source: Dithioerythritol-capped silver/gold nanoclusters for determination of ciprofloxacin, norfloxacin, and enrofloxacin in food and urine samples · DOI · quote verified
What LODs (S/N = 3) were reported?
3.1 nM CIP, 3.8 nM NOR, 4.4 nM ENR.
Source: Dithioerythritol-capped silver/gold nanoclusters for determination of ciprofloxacin, norfloxacin, and enrofloxacin in food and urine samples · DOI · quote verified
How did Al3+ change quantum yield?
From 3.28% (clusters) to 12.89% (clusters/Al3+).
Source: Dithioerythritol-capped silver/gold nanoclusters for determination of ciprofloxacin, norfloxacin, and enrofloxacin in food and urine samples · DOI · quote verified
How did fluorescence lifetimes change?
11.03 ns without Al3+ versus 17.89 ns with Al3+.
Source: Dithioerythritol-capped silver/gold nanoclusters for determination of ciprofloxacin, norfloxacin, and enrofloxacin in food and urine samples · DOI · quote verified
What DLS diameters were measured along the sensing cascade?
118.2 nm (NCs), 432.2 nm (NCs/Al3+), 152.89 nm (NCs/Al3+/CIP).
Source: Dithioerythritol-capped silver/gold nanoclusters for determination of ciprofloxacin, norfloxacin, and enrofloxacin in food and urine samples · DOI · quote verified
How accurate were recoveries in real samples?
94.0–106.0% with RSD < 4.09%.
Source: Dithioerythritol-capped silver/gold nanoclusters for determination of ciprofloxacin, norfloxacin, and enrofloxacin in food and urine samples · DOI · quote verified
How fast is the probe response?
1.5 min under optimal conditions.
Source: Dithioerythritol-capped silver/gold nanoclusters for determination of ciprofloxacin, norfloxacin, and enrofloxacin in food and urine samples · DOI · quote verified
What HPLC-UV retention times benchmarked the three FQs?
CIP 4.55 min, NOR 5.12 min, ENR 5.87 min at 280 nm.
Source: Dithioerythritol-capped silver/gold nanoclusters for determination of ciprofloxacin, norfloxacin, and enrofloxacin in food and urine samples · DOI · quote verified
Did common ions and other antibiotics interfere?
Minimal effect even at 10× the FQ concentration.
Source: Dithioerythritol-capped silver/gold nanoclusters for determination of ciprofloxacin, norfloxacin, and enrofloxacin in food and urine samples · DOI · quote verified
What limitations do the authors list?
Cannot distinguish mixed FQs; not tested in blood.
Source: Dithioerythritol-capped silver/gold nanoclusters for determination of ciprofloxacin, norfloxacin, and enrofloxacin in food and urine samples · DOI · quote verified