Flashcard library · Biology · PaperFren
A DNA methylation clock for human age
A 353-CpG epigenetic clock predicts age across diverse human tissues.
Keep what you just learned
Save these 10 cards to your NoteFren library. Your first review starts right away, and each card links back to the study it came from.
What does the clock predict?
Chronological age from DNA methylation.
Source: DNA methylation age of human tissues and cell types · DOI · quote verified
How many clock CpGs?
353 selected by elastic net.
Source: DNA methylation age of human tissues and cell types · DOI · quote verified
Sample scope?
Thousands of non-cancer samples across tissues.
Source: DNA methylation age of human tissues and cell types · DOI · quote verified
Platforms used?
Illumina 27K and 450K arrays.
Source: DNA methylation age of human tissues and cell types · DOI · quote verified
Cross-tissue?
Designed to work across many tissues.
Source: DNA methylation age of human tissues and cell types · DOI · quote verified
What is DNAm here?
Cytosine-5 methylation at CpGs.
Source: DNA methylation age of human tissues and cell types · DOI · quote verified
Train/test structure?
Separate dataset groups for training and validation.
Source: DNA methylation age of human tissues and cell types · DOI · quote verified
Stem/iPS DNAm age?
Appears young / reset.
Source: DNA methylation age of human tissues and cell types · DOI · quote verified
Why aging epigenetics?
Age-related methylation changes are widespread.
Source: DNA methylation age of human tissues and cell types · DOI · quote verified
Takeaway?
Methylation patterns can timestamp human samples.
Source: DNA methylation age of human tissues and cell types · DOI · quote verified