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Genetics shapes methylation and expression
In HapMap LCLs, promoter methylation associates with genetic variants and transcript levels.
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Cell type?
HapMap lymphoblastoid cell lines.
Source: DNA methylation patterns associate with genetic and gene expression variation in HapMap cell lines · DOI · quote verified
Measurement?
Genome-wide promoter DNA methylation.
Source: DNA methylation patterns associate with genetic and gene expression variation in HapMap cell lines · DOI · quote verified
Genetic resource?
Dense HapMap genotypes.
Source: DNA methylation patterns associate with genetic and gene expression variation in HapMap cell lines · DOI · quote verified
Expression resource?
RNA-seq for most samples.
Source: DNA methylation patterns associate with genetic and gene expression variation in HapMap cell lines · DOI · quote verified
Main finding?
Methylation associates with genetic and expression variation.
Source: DNA methylation patterns associate with genetic and gene expression variation in HapMap cell lines · DOI · quote verified
Probe scale?
Tens of thousands of CpG sites.
Source: DNA methylation patterns associate with genetic and gene expression variation in HapMap cell lines · DOI · quote verified
Population?
Yoruba (YRI) individuals.
Source: DNA methylation patterns associate with genetic and gene expression variation in HapMap cell lines · DOI · quote verified
X chromosome?
Sex-specific methylation patterns.
Source: DNA methylation patterns associate with genetic and gene expression variation in HapMap cell lines · DOI · quote verified
Near TSS?
Methylation drops near transcription start sites.
Source: DNA methylation patterns associate with genetic and gene expression variation in HapMap cell lines · DOI · quote verified
Takeaway?
Sequence variation shapes epigenome and transcriptome.
Source: DNA methylation patterns associate with genetic and gene expression variation in HapMap cell lines · DOI · quote verified