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Child chemical mixtures and ADHD scores
A childhood phthalate mixture, weighted toward DEHP metabolites, tracked higher ADHD scores, mainly in autistic children.
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Cohort and ages?
CHARGE 2- to 5-year-olds with ASD, DD, or typical development.
Source: Early childhood exposure to environmental phenols and parabens, phthalates, organophosphate pesticides, and trace elements in association with attention deficit hyperactivity disorder (ADHD) symptoms in the CHARGE study · DOI · quote verified
How many children per diagnosis?
ASD 225, DD 88, TD 236.
Source: Early childhood exposure to environmental phenols and parabens, phthalates, organophosphate pesticides, and trace elements in association with attention deficit hyperactivity disorder (ADHD) symptoms in the CHARGE study · DOI · quote verified
How many chemicals were quantified?
62 urinary analytes.
Source: Early childhood exposure to environmental phenols and parabens, phthalates, organophosphate pesticides, and trace elements in association with attention deficit hyperactivity disorder (ADHD) symptoms in the CHARGE study · DOI · quote verified
How many chemicals entered statistics?
43 with detection over 70%.
Source: Early childhood exposure to environmental phenols and parabens, phthalates, organophosphate pesticides, and trace elements in association with attention deficit hyperactivity disorder (ADHD) symptoms in the CHARGE study · DOI · quote verified
Mixture method?
Weighted quantile sum (WQS) regression.
Source: Early childhood exposure to environmental phenols and parabens, phthalates, organophosphate pesticides, and trace elements in association with attention deficit hyperactivity disorder (ADHD) symptoms in the CHARGE study · DOI · quote verified
Phthalate mixture finding?
Associated with ADHD symptoms, especially hyperactivity and impulsivity.
Source: Early childhood exposure to environmental phenols and parabens, phthalates, organophosphate pesticides, and trace elements in association with attention deficit hyperactivity disorder (ADHD) symptoms in the CHARGE study · DOI · quote verified
Who drove the associations?
Children with ASD, not DD or TD alone.
Source: Early childhood exposure to environmental phenols and parabens, phthalates, organophosphate pesticides, and trace elements in association with attention deficit hyperactivity disorder (ADHD) symptoms in the CHARGE study · DOI · quote verified
Single-chemical DEHP result?
DEHP metabolites associated with increased hyperactivity and impulsivity.
Source: Early childhood exposure to environmental phenols and parabens, phthalates, organophosphate pesticides, and trace elements in association with attention deficit hyperactivity disorder (ADHD) symptoms in the CHARGE study · DOI · quote verified
Share male?
80.1%.
Source: Early childhood exposure to environmental phenols and parabens, phthalates, organophosphate pesticides, and trace elements in association with attention deficit hyperactivity disorder (ADHD) symptoms in the CHARGE study · DOI · quote verified
Key limit?
Reverse causality via autism-related diet and product use cannot be ruled out.
Source: Early childhood exposure to environmental phenols and parabens, phthalates, organophosphate pesticides, and trace elements in association with attention deficit hyperactivity disorder (ADHD) symptoms in the CHARGE study · DOI · quote verified
Mixture chemicals of concern in ASD?
A phenol (DHB34), several phthalates, and cadmium.
Source: Early childhood exposure to environmental phenols and parabens, phthalates, organophosphate pesticides, and trace elements in association with attention deficit hyperactivity disorder (ADHD) symptoms in the CHARGE study · DOI · quote verified