Deprexis online therapy reduced depression scores

An integrative online program (Deprexis) improved BDI depression symptoms versus delayed treatment in a large German internet RCT.

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How many participants were included?

396 individuals (81% immediate, 19% delayed).

How much did immediate treatment change BDI?

Improved 5.4 points (26.72 to 21.30), d=0.58.

Was the BDI condition×time interaction significant?

Yes—F=19.2, P<.001.

What happened in the delayed-treatment arm T0–T1?

No significant BDI change (d=.01).

What program was tested?

Deprexis, an integrative online depression treatment.

How were participants recruited?

Internet advertisements such as depression-related forums in Germany.

What demographic pattern was noted?

About three-quarters were women; average age around 35.

Were ITT effects weaker than completer analyses?

Yes—significant but weaker ITT effect sizes (e.g., d=.30 between groups at T1).

What broader conclusion did authors state?

Program users had lasting symptom reductions while non-users stayed distressed.

Why does treating depression matter societally per intro?

High personal suffering plus treatment and productivity costs.

What secondary functioning pattern was noted?

Social dysfunction decreased slightly in immediate treatment but not delayed.