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Holstein GWAS across 31 dairy traits
Genome-wide SNP association in U.S. Holsteins links many loci to production, health, fertility, and type traits.
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Species/breed?
U.S. Holstein cattle.
Source: Genome-wide association analysis of thirty one production, health, reproduction and body conformation traits in contemporary U.S. Holstein cows · DOI · quote verified
How many traits?
Thirty-one dairy traits.
Source: Genome-wide association analysis of thirty one production, health, reproduction and body conformation traits in contemporary U.S. Holstein cows · DOI · quote verified
Marker panel scale?
Tens of thousands of SNPs.
Source: Genome-wide association analysis of thirty one production, health, reproduction and body conformation traits in contemporary U.S. Holstein cows · DOI · quote verified
Effect type reported?
Additive SNP effects.
Source: Genome-wide association analysis of thirty one production, health, reproduction and body conformation traits in contemporary U.S. Holstein cows · DOI · quote verified
Significance burden?
Stringent genome-wide Bonferroni thresholds.
Source: Genome-wide association analysis of thirty one production, health, reproduction and body conformation traits in contemporary U.S. Holstein cows · DOI · quote verified
Top hits reporting?
Top 100 effects per trait summarized.
Source: Genome-wide association analysis of thirty one production, health, reproduction and body conformation traits in contemporary U.S. Holstein cows · DOI · quote verified
Gene overlap?
Many top SNPs lie in annotated genes.
Source: Genome-wide association analysis of thirty one production, health, reproduction and body conformation traits in contemporary U.S. Holstein cows · DOI · quote verified
Pleiotropy?
Some SNPs affect many traits.
Source: Genome-wide association analysis of thirty one production, health, reproduction and body conformation traits in contemporary U.S. Holstein cows · DOI · quote verified
Why GWAS in dairy?
Map QTL for genomic selection/biology.
Source: Genome-wide association analysis of thirty one production, health, reproduction and body conformation traits in contemporary U.S. Holstein cows · DOI · quote verified
Takeaway?
Complex dairy traits have polygenic SNP architectures.
Source: Genome-wide association analysis of thirty one production, health, reproduction and body conformation traits in contemporary U.S. Holstein cows · DOI · quote verified