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Pathogenicity factors in Naegleria fowleri
Whole-genome analysis of N. fowleri highlights candidate pathogenicity factors for brain infection.
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Pathogen?
Naegleria fowleri.
Source: Genome-wide identification of pathogenicity factors of the free-living amoeba Naegleria fowleri · DOI · quote verified
Human disease?
Primary amoebic meningoencephalitis.
Source: Genome-wide identification of pathogenicity factors of the free-living amoeba Naegleria fowleri · DOI · quote verified
Approach?
Whole-genome sequencing plus comparative analysis.
Source: Genome-wide identification of pathogenicity factors of the free-living amoeba Naegleria fowleri · DOI · quote verified
Genome size scale?
About 30 Mb nuclear genome.
Source: Genome-wide identification of pathogenicity factors of the free-living amoeba Naegleria fowleri · DOI · quote verified
GC content?
AT-rich (~35% GC).
Source: Genome-wide identification of pathogenicity factors of the free-living amoeba Naegleria fowleri · DOI · quote verified
Why urgent?
Rapid lethal disease with poor treatments.
Source: Genome-wide identification of pathogenicity factors of the free-living amoeba Naegleria fowleri · DOI · quote verified
Infection route?
Contaminated water to nose/olfactory nerve.
Source: Genome-wide identification of pathogenicity factors of the free-living amoeba Naegleria fowleri · DOI · quote verified
Output?
Candidate pathogenicity factor gene sets.
Source: Genome-wide identification of pathogenicity factors of the free-living amoeba Naegleria fowleri · DOI · quote verified
Assembly evidence?
High-coverage hybrid Illumina/454 assembly.
Source: Genome-wide identification of pathogenicity factors of the free-living amoeba Naegleria fowleri · DOI · quote verified
Takeaway?
Genomes can nominate amoeba virulence machinery.
Source: Genome-wide identification of pathogenicity factors of the free-living amoeba Naegleria fowleri · DOI · quote verified