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Pregnancy PFAS and lead track lower birth weight
In Cincinnati’s HOME Study, PFAS, lead, and organophosphate pesticides associated with lower birth weight; phthalates and BPA did not.
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What cohort?
HOME Study, a Cincinnati prospective birth cohort.
Source: Gestational exposure to endocrine disrupting chemicals in relation to infant birth weight: a Bayesian analysis of the HOME Study · DOI · quote verified
When were women recruited?
Prenatal clinics between 2003 and 2006, at 13–19 weeks of pregnancy.
Source: Gestational exposure to endocrine disrupting chemicals in relation to infant birth weight: a Bayesian analysis of the HOME Study · DOI · quote verified
How many births entered the models?
272 of 389 singleton live births (69.9%).
Source: Gestational exposure to endocrine disrupting chemicals in relation to infant birth weight: a Bayesian analysis of the HOME Study · DOI · quote verified
When were exposure biomarkers collected?
Blood and urine at about 16 and 26 weeks gestation.
Source: Gestational exposure to endocrine disrupting chemicals in relation to infant birth weight: a Bayesian analysis of the HOME Study · DOI · quote verified
What mixture method is featured?
Bayesian hierarchical linear models (BHLM) that shrink correlated coefficients.
Source: Gestational exposure to endocrine disrupting chemicals in relation to infant birth weight: a Bayesian analysis of the HOME Study · DOI · quote verified
Phthalates and BPA versus birth weight?
Class mean about +1 g per 10-fold exposure, not statistically significant.
Source: Gestational exposure to endocrine disrupting chemicals in relation to infant birth weight: a Bayesian analysis of the HOME Study · DOI · quote verified
What did all 5 PFAS show?
Associations with reductions in birth weight, though 95% CIs included zero.
Source: Gestational exposure to endocrine disrupting chemicals in relation to infant birth weight: a Bayesian analysis of the HOME Study · DOI · quote verified
PFAS class estimate?
About −11 g (50% CI −21 to −2).
Source: Gestational exposure to endocrine disrupting chemicals in relation to infant birth weight: a Bayesian analysis of the HOME Study · DOI · quote verified
Which other exposures tracked lower birth weight?
Lead (Pb) and organophosphate pesticides, plus PFAS.
Source: Gestational exposure to endocrine disrupting chemicals in relation to infant birth weight: a Bayesian analysis of the HOME Study · DOI · quote verified
Smoking contrast?
210 g lower birth weight if maternal cotinine >3 ng/ml.
Source: Gestational exposure to endocrine disrupting chemicals in relation to infant birth weight: a Bayesian analysis of the HOME Study · DOI · quote verified
Why might phthalate/BPA effects be attenuated?
Short half-lives and measurement error for non-persistent chemicals.
Source: Gestational exposure to endocrine disrupting chemicals in relation to infant birth weight: a Bayesian analysis of the HOME Study · DOI · quote verified