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Shingles vaccine cut zoster by about half
In older US adults, herpes zoster vaccination showed ~48% effectiveness against incident zoster and ~59–62% against post-herpetic neuralgia.
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What overall VE against incident zoster was reported?
48% overall VE against incident herpes zoster.
Source: Herpes zoster vaccine effectiveness against incident herpes zoster and post-herpetic neuralgia in an older US population: a cohort study · DOI · quote verified
What adjusted VE for zoster was estimated?
0.48 (95% CI 0.39–0.56) after demographic/clinical adjustment.
Source: Herpes zoster vaccine effectiveness against incident herpes zoster and post-herpetic neuralgia in an older US population: a cohort study · DOI · quote verified
What was VE against PHN at ≥90 days?
Adjusted VE 0.59 (95% CI 0.21–0.79).
Source: Herpes zoster vaccine effectiveness against incident herpes zoster and post-herpetic neuralgia in an older US population: a cohort study · DOI · quote verified
How large was the eligible cohort and uptake?
766,330 eligible; 29,785 vaccinated (3.9%).
Source: Herpes zoster vaccine effectiveness against incident herpes zoster and post-herpetic neuralgia in an older US population: a cohort study · DOI · quote verified
What uptake disparities were noted?
Lower in age ≥80, Black individuals, and low-income groups.
Source: Herpes zoster vaccine effectiveness against incident herpes zoster and post-herpetic neuralgia in an older US population: a cohort study · DOI · quote verified
What overall conclusion was stated?
Vaccination significantly reduced incident zoster and PHN in routine use.
Source: Herpes zoster vaccine effectiveness against incident herpes zoster and post-herpetic neuralgia in an older US population: a cohort study · DOI · quote verified
How was vaccination identified?
CPT code 90736 in claims.
Source: Herpes zoster vaccine effectiveness against incident herpes zoster and post-herpetic neuralgia in an older US population: a cohort study · DOI · quote verified
How was incident zoster defined?
Episode without zoster/PHN evidence for at least 1 prior year.
Source: Herpes zoster vaccine effectiveness against incident herpes zoster and post-herpetic neuralgia in an older US population: a cohort study · DOI · quote verified
Why do immunosuppressed patients matter?
Highest risk of zoster/complications; VE evidence still limited but supportive.
Source: Herpes zoster vaccine effectiveness against incident herpes zoster and post-herpetic neuralgia in an older US population: a cohort study · DOI · quote verified
What ethics approvals were obtained?
CMS data-use agreement and LSHTM ethics committee.
Source: Herpes zoster vaccine effectiveness against incident herpes zoster and post-herpetic neuralgia in an older US population: a cohort study · DOI · quote verified
What prior RCT efficacy context was cited?
Prior RCT efficacy ~51% against zoster and 67% against PHN in older adults.
Source: Herpes zoster vaccine effectiveness against incident herpes zoster and post-herpetic neuralgia in an older US population: a cohort study · DOI · quote verified