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Phthalates, thyroid hormones, and adult blood lipids
In 222 Taiwanese adults, urinary phthalate metabolites tracked with thyroid hormones and lipid markers; T4 appeared to sit on the path from DEHP metabolites to HDL-C, but that mediation interval included the null.
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How many adults entered the final analysis?
222.
Source: Mediation effects of thyroid function in the associations between phthalate exposure and lipid metabolism in adults · DOI · quote verified
Which phthalate metabolite associated with lower LDL-C?
MMP (β = −0.036).
Source: Mediation effects of thyroid function in the associations between phthalate exposure and lipid metabolism in adults · DOI · quote verified
What did MEP associate with?
Lower total cholesterol and NHC.
Source: Mediation effects of thyroid function in the associations between phthalate exposure and lipid metabolism in adults · DOI · quote verified
What did ΣDEHP metabolites associate with?
Higher HDL-C.
Source: Mediation effects of thyroid function in the associations between phthalate exposure and lipid metabolism in adults · DOI · quote verified
What fraction of the ΣDEHPm–HDL-C link was attributed to T4?
32.2%, but the indirect effect was not significant.
Source: Mediation effects of thyroid function in the associations between phthalate exposure and lipid metabolism in adults · DOI · quote verified
Did the authors still interpret thyroid hormones as mediators?
Yes—they concluded thyroid hormones, especially T4, mediate phthalates and lipids.
Source: Mediation effects of thyroid function in the associations between phthalate exposure and lipid metabolism in adults · DOI · quote verified
Why might thyroid hormones sit on this path?
They stimulate lipid synthesis and promote lipolysis.
Source: Mediation effects of thyroid function in the associations between phthalate exposure and lipid metabolism in adults · DOI · quote verified
What exposure matrix was used for phthalates?
Urinary metabolites, including molar sums of DEHP and DBP metabolites.
Source: Mediation effects of thyroid function in the associations between phthalate exposure and lipid metabolism in adults · DOI · quote verified
Average age and BMI?
About 52.2 years and BMI 24.8.
Source: Mediation effects of thyroid function in the associations between phthalate exposure and lipid metabolism in adults · DOI · quote verified
What plastic-use habits were common?
Most used plastic wrap, containers, and bags.
Source: Mediation effects of thyroid function in the associations between phthalate exposure and lipid metabolism in adults · DOI · quote verified
Is the T4 mediation interval conclusive?
No—the 95% CI for the indirect effect included zero.
Source: Mediation effects of thyroid function in the associations between phthalate exposure and lipid metabolism in adults · DOI · quote verified