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Mediterranean diet and depression risk
Overall Mediterranean diet assignment did not significantly reduce depression; a nuts arm suggested benefit in diabetes subgroup analyses.
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Overall merged MD?
No significant reduction (HR 0.85).
Source: Mediterranean dietary pattern and depression: the PREDIMED randomized trial · DOI · quote verified
Cases?
224.
Source: Mediterranean dietary pattern and depression: the PREDIMED randomized trial · DOI · quote verified
Follow-up?
5.4 years median.
Source: Mediterranean dietary pattern and depression: the PREDIMED randomized trial · DOI · quote verified
MD-nuts overall?
Inverse but nonsignificant.
Source: Mediterranean dietary pattern and depression: the PREDIMED randomized trial · DOI · quote verified
DM2 subgroup?
Significant depression reduction for MD-nuts.
Source: Mediterranean dietary pattern and depression: the PREDIMED randomized trial · DOI · quote verified
3-year diet data?
2,513 participants.
Source: Mediterranean dietary pattern and depression: the PREDIMED randomized trial · DOI · quote verified
Arms?
MD-EVOO, MD-nuts, low-fat control.
Source: Mediterranean dietary pattern and depression: the PREDIMED randomized trial · DOI · quote verified
Population?
High CVD-risk adults.
Source: Mediterranean dietary pattern and depression: the PREDIMED randomized trial · DOI · quote verified
Limit?
Secondary endpoint; caution on subgroups.
Source: Mediterranean dietary pattern and depression: the PREDIMED randomized trial · DOI · quote verified
Takeaway?
Overall MD alone did not clearly prevent depression.
Source: Mediterranean dietary pattern and depression: the PREDIMED randomized trial · DOI · quote verified