What proteins build the caveolar coat?

Caveolins and cavins purify as a caveolar coat complex with Cavin 1 as a core trimeric component.

Keep what you just learned

Save these 10 cards to your NoteFren library. Your first review starts right away, and each card links back to the study it came from.

What complex do caveolins and cavins form?

A single caveolar coat complex.

What proteins are excluded from that complex?

EHD2 and pacsin 2.

What do authors name the complex?

The caveolar coat complex.

Which cavin is a core component?

Cavin 1.

What oligomer evidence for Cavin 1?

Several experiments support Cavin 1 forming a trimer.

What membrane structure are caveolae?

~50–80 nm flask-like plasma-membrane invaginations.

Which protein is essential for caveolae in nonmuscle cells?

Caveolin 1.

Where are caveolae especially abundant?

Endothelial cells, adipocytes, and muscle cells.

What does quantitative analysis enable?

A model of basic stoichiometry of the coat.

What broader cell-biology lesson?

Caveolae have a defined multiprotein coat, not just caveolin alone.