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OSA severity and cardiovascular risk
In >10,000 sleep-study patients, higher apnea–hypopnea burden predicted cardiovascular events and death over years of follow-up.
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Analysed N?
10,149 linked patients.
Source: Obstructive sleep apnea and risk of cardiovascular events and all-cause mortality: a decade-long historical cohort study · DOI · quote verified
Event rate?
11.5% composite over median 68 months.
Source: Obstructive sleep apnea and risk of cardiovascular events and all-cause mortality: a decade-long historical cohort study · DOI · quote verified
Incidence density?
About 2 per 100 person-years.
Source: Obstructive sleep apnea and risk of cardiovascular events and all-cause mortality: a decade-long historical cohort study · DOI · quote verified
AHI association?
Higher AHI linked to higher hazard (HR 1.49 high vs low).
Source: Obstructive sleep apnea and risk of cardiovascular events and all-cause mortality: a decade-long historical cohort study · DOI · quote verified
Sample profile?
62% male; mean age 50; mean AHI 25.
Source: Obstructive sleep apnea and risk of cardiovascular events and all-cause mortality: a decade-long historical cohort study · DOI · quote verified
Design?
Decade-long historical cohort after sleep study.
Source: Obstructive sleep apnea and risk of cardiovascular events and all-cause mortality: a decade-long historical cohort study · DOI · quote verified
Outcomes?
Composite cardiovascular events and all-cause mortality.
Source: Obstructive sleep apnea and risk of cardiovascular events and all-cause mortality: a decade-long historical cohort study · DOI · quote verified
Sleep metrics beyond AHI?
Oxygen desaturation time also considered.
Source: Obstructive sleep apnea and risk of cardiovascular events and all-cause mortality: a decade-long historical cohort study · DOI · quote verified
Limit?
Referral cohort; observational confounding.
Source: Obstructive sleep apnea and risk of cardiovascular events and all-cause mortality: a decade-long historical cohort study · DOI · quote verified
Takeaway?
OSA physiologic burden tracks long-term CV risk.
Source: Obstructive sleep apnea and risk of cardiovascular events and all-cause mortality: a decade-long historical cohort study · DOI · quote verified