How does food reset the liver clock?

The gut incretin oxyntomodulin (OXM) links food intake to resetting of the hepatic circadian clock and metabolism.

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Which peptide links gut food intake to liver clock resetting?

Oxyntomodulin (OXM).

What happens if eating occurs in the rest phase?

Internal circadian desynchrony.

Is food entrainment only glucose-dependent?

No—not exclusively dependent on glucose.

What health context motivates peripheral clock disruption?

Shiftwork-associated metabolic and other risks.

What are CLOCK and BMAL1?

Core transcriptional activators of the circadian TTL.

What process resets peripheral tissue clocks here?

Food intake.

Target organ emphasized?

Liver (hepatic clock and metabolism).

What class of signal is OXM?

An incretin peptide from the gut.

Why study non-glucose food cues?

Molecular mechanisms of food entrainment of peripheral clocks remain incomplete.

Student takeaway?

Gut hormones can act as food-related Zeitgebers for liver clocks.