Flashcard library · Environmental Science · PaperFren
Cord-blood PFBS linked to preeclampsia in Shanghai
Among Shanghai births, higher standardized cord PFBS associated with preeclampsia (AOR 1.81) and overall hypertensive disorders of pregnancy (AOR 1.64) in a dose-response pattern.
Keep what you just learned
Save these 10 cards to your NoteFren library. Your first review starts right away, and each card links back to the study it came from.
What outcome class was studied?
Hypertensive disorders of pregnancy, including preeclampsia.
Source: Prenatal exposure to perfluoroalkyl and polyfluoroalkyl substances and the risk of hypertensive disorders of pregnancy · DOI · quote verified
Where were mothers recruited?
Two large hospitals in Shanghai.
Source: Prenatal exposure to perfluoroalkyl and polyfluoroalkyl substances and the risk of hypertensive disorders of pregnancy · DOI · quote verified
HDP and preeclampsia rates?
6.1% HDP and 2.8% preeclampsia (3.3% gestational hypertension).
Source: Prenatal exposure to perfluoroalkyl and polyfluoroalkyl substances and the risk of hypertensive disorders of pregnancy · DOI · quote verified
Which PFAS had the highest median?
PFOA at 6.98 ng/ml.
Source: Prenatal exposure to perfluoroalkyl and polyfluoroalkyl substances and the risk of hypertensive disorders of pregnancy · DOI · quote verified
Median PFBS?
0.047 ng/ml, yet it was selected for HDP/preeclampsia.
Source: Prenatal exposure to perfluoroalkyl and polyfluoroalkyl substances and the risk of hypertensive disorders of pregnancy · DOI · quote verified
AOR for HDP per standardized PFBS unit?
1.64 (95% CI 1.09–2.47).
Source: Prenatal exposure to perfluoroalkyl and polyfluoroalkyl substances and the risk of hypertensive disorders of pregnancy · DOI · quote verified
AOR for preeclampsia?
1.81 (95% CI 1.03–3.17).
Source: Prenatal exposure to perfluoroalkyl and polyfluoroalkyl substances and the risk of hypertensive disorders of pregnancy · DOI · quote verified
How were mixed PFAS handled?
Elastic net selected PFBS (with PFHxS/PFDoA or PFUA) then unpenalized logistic models.
Source: Prenatal exposure to perfluoroalkyl and polyfluoroalkyl substances and the risk of hypertensive disorders of pregnancy · DOI · quote verified
Authors’ conclusion on PFBS?
Cord PFBS positively associated with preeclampsia in a dose-response pattern.
Source: Prenatal exposure to perfluoroalkyl and polyfluoroalkyl substances and the risk of hypertensive disorders of pregnancy · DOI · quote verified
Why might short-chain PFBS still matter?
It is a PFOS replacement now found in cord blood.
Source: Prenatal exposure to perfluoroalkyl and polyfluoroalkyl substances and the risk of hypertensive disorders of pregnancy · DOI · quote verified