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Prenatal PFAS tracked 5-year child overweight risk
In 412 Scandinavian mother–child pairs, higher maternal PFAS associated with higher child BMI and triceps skinfold z-scores and with overweight/obesity at age 5, with geographic differences.
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How many mother–child pairs were analyzed?
412 from Norway and Sweden.
Source: Prenatal exposure to persistent organic pollutants and child overweight/obesity at 5-year follow-up: a prospective cohort study · DOI · quote verified
What age-5 outcome besides BMI?
Overweight/obesity and skinfold z-scores.
Source: Prenatal exposure to persistent organic pollutants and child overweight/obesity at 5-year follow-up: a prospective cohort study · DOI · quote verified
How many children were overweight/obese at 5?
55 (12%); 14% Norway vs 10% Sweden.
Source: Prenatal exposure to persistent organic pollutants and child overweight/obesity at 5-year follow-up: a prospective cohort study · DOI · quote verified
What did increasing maternal PFAS associate with?
Higher child BMI and triceps skinfold z-scores plus overweight/obesity.
Source: Prenatal exposure to persistent organic pollutants and child overweight/obesity at 5-year follow-up: a prospective cohort study · DOI · quote verified
Did the PFAS association look the same everywhere?
No—it may differ geographically and by maternal concentration.
Source: Prenatal exposure to persistent organic pollutants and child overweight/obesity at 5-year follow-up: a prospective cohort study · DOI · quote verified
Why use skinfolds instead of BMI alone?
Same BMI can hide different fat mass.
Source: Prenatal exposure to persistent organic pollutants and child overweight/obesity at 5-year follow-up: a prospective cohort study · DOI · quote verified
What dose-response issue do authors highlight?
Need to assess non-monotonic (NMDR) relationships for POP exposures.
Source: Prenatal exposure to persistent organic pollutants and child overweight/obesity at 5-year follow-up: a prospective cohort study · DOI · quote verified
Mean maternal age at start?
29 years.
Source: Prenatal exposure to persistent organic pollutants and child overweight/obesity at 5-year follow-up: a prospective cohort study · DOI · quote verified
Country difference in maternal smoking at conception?
53% Norway vs 33% Sweden.
Source: Prenatal exposure to persistent organic pollutants and child overweight/obesity at 5-year follow-up: a prospective cohort study · DOI · quote verified
Was the sample a simple random birth cohort?
No—SGA births were oversampled (about one-third of followed children).
Source: Prenatal exposure to persistent organic pollutants and child overweight/obesity at 5-year follow-up: a prospective cohort study · DOI · quote verified