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How open is the Listeria pan-genome?
Eleven new genomes spanning serotypes show a stable but open pan-genome with nine hypervariable hotspots dominated by mobile elements.
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Is the pan-genome closed?
No—highly stable but not closed.
Source: Reassessment of the Listeria monocytogenes pan-genome reveals dynamic integration hotspots and mobile genetic elements as major components of the accessory genome · DOI · quote verified
How many hypervariable hotspots are highlighted?
Nine.
Source: Reassessment of the Listeria monocytogenes pan-genome reveals dynamic integration hotspots and mobile genetic elements as major components of the accessory genome · DOI · quote verified
How many strains were added?
11 strains covering serotypes.
Source: Reassessment of the Listeria monocytogenes pan-genome reveals dynamic integration hotspots and mobile genetic elements as major components of the accessory genome · DOI · quote verified
What dominate the accessory genome?
Mobile genetic elements.
Source: Reassessment of the Listeria monocytogenes pan-genome reveals dynamic integration hotspots and mobile genetic elements as major components of the accessory genome · DOI · quote verified
Why add genomes across serotypes?
To enable deeper evolutionary analyses.
Source: Reassessment of the Listeria monocytogenes pan-genome reveals dynamic integration hotspots and mobile genetic elements as major components of the accessory genome · DOI · quote verified
Practical uses of presence/absence maps?
Diagnostic, phylogenetic, and functional research.
Source: Reassessment of the Listeria monocytogenes pan-genome reveals dynamic integration hotspots and mobile genetic elements as major components of the accessory genome · DOI · quote verified
How many lineages/serotypes are noted?
Four evolutionary lineages and 12 serotypes.
Source: Reassessment of the Listeria monocytogenes pan-genome reveals dynamic integration hotspots and mobile genetic elements as major components of the accessory genome · DOI · quote verified
How is Listeria framed scientifically?
A well-characterized pathogen and infection model.
Source: Reassessment of the Listeria monocytogenes pan-genome reveals dynamic integration hotspots and mobile genetic elements as major components of the accessory genome · DOI · quote verified
What does 'not closed' imply?
New accessory genes can still enter the species pool.
Source: Reassessment of the Listeria monocytogenes pan-genome reveals dynamic integration hotspots and mobile genetic elements as major components of the accessory genome · DOI · quote verified
Student takeaway?
Pathogen diversity is shaped by hotspots and mobile DNA beyond a fixed core.
Source: Reassessment of the Listeria monocytogenes pan-genome reveals dynamic integration hotspots and mobile genetic elements as major components of the accessory genome · DOI · quote verified