Can Cas13a fight RNA viruses in plants?

CRISPR/Cas13a interferes with TuMV in plants, cutting viral RNA and reducing reporter/virus accumulation.

Keep what you just learned

Save these 10 cards to your NoteFren library. Your first review starts right away, and each card links back to the study it came from.

Which effector targeted TuMV?

Cas13a.

What did data demonstrate?

Cas13a mediates molecular interference against a plant RNA virus.

Effect of targeting different viral regions?

Reduced GFP and reduced viral accumulation.

Natural CRISPR role?

Immunity to invading nucleic acids in bacteria/archaea.

Cited applications?

Functional biology, biotechnology, and genetic medicine.

Virus class?

RNA virus (TuMV).

Host system?

Plants.

What enables selectivity?

Guides to chosen viral genomic regions.

Class II CRISPR types include?

Types II, V, and VI.

Student takeaway?

RNA-targeting Cas13 can be a programmable plant antiviral.