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Serum phthalates track adipose redox markers
In 308 Spanish adults, low-molecular-weight phthalates associated with higher GPx and TBARS in fat, while a phthalate mixture index associated with lower GSH and GSSG.
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How many participants had adipose oxidative-stress markers?
308; 8OHdG was limited to 112 with enough tissue.
Source: Serum Phthalate Concentrations and Biomarkers of Oxidative Stress in Adipose Tissue in a Spanish Adult Cohort · DOI · quote verified
Which phthalate metabolite was most abundant in serum?
MEP, followed by MMP.
Source: Serum Phthalate Concentrations and Biomarkers of Oxidative Stress in Adipose Tissue in a Spanish Adult Cohort · DOI · quote verified
How did LMWP metabolites relate to GPx and TBARS?
Positive associations for MMP, MiBP, and MnBP.
Source: Serum Phthalate Concentrations and Biomarkers of Oxidative Stress in Adipose Tissue in a Spanish Adult Cohort · DOI · quote verified
How did the HMWP metabolite MiNP relate to those markers?
Negatively associated with GPx and TBARS.
Source: Serum Phthalate Concentrations and Biomarkers of Oxidative Stress in Adipose Tissue in a Spanish Adult Cohort · DOI · quote verified
What did the WQS mixture index do to GSH?
Significant negative association (β = −30.089, p = 0.025).
Source: Serum Phthalate Concentrations and Biomarkers of Oxidative Stress in Adipose Tissue in a Spanish Adult Cohort · DOI · quote verified
Which metabolites dominated the negative GSH mixture?
MEHP (25%) and MECPP (21%).
Source: Serum Phthalate Concentrations and Biomarkers of Oxidative Stress in Adipose Tissue in a Spanish Adult Cohort · DOI · quote verified
What dominated the negative GSSG mixture?
MiBP (27%) and MnBP (18%).
Source: Serum Phthalate Concentrations and Biomarkers of Oxidative Stress in Adipose Tissue in a Spanish Adult Cohort · DOI · quote verified
How many phthalate metabolites were targeted in serum?
32 metabolites from 15 parent diesters by online TurboFlow LC–MS/MS.
Source: Serum Phthalate Concentrations and Biomarkers of Oxidative Stress in Adipose Tissue in a Spanish Adult Cohort · DOI · quote verified
Why was 8OHdG n smaller?
Only 112 people had adequate biological sample for that assay.
Source: Serum Phthalate Concentrations and Biomarkers of Oxidative Stress in Adipose Tissue in a Spanish Adult Cohort · DOI · quote verified
What overall pattern did the authors emphasize?
Novel links between phthalate metabolites and in-situ adipose redox biomarkers.
Source: Serum Phthalate Concentrations and Biomarkers of Oxidative Stress in Adipose Tissue in a Spanish Adult Cohort · DOI · quote verified
How were metabolites below LOD handled?
Replaced by random numbers between 0 and the LOD, except MBzP and MiDP which were dichotomized.
Source: Serum Phthalate Concentrations and Biomarkers of Oxidative Stress in Adipose Tissue in a Spanish Adult Cohort · DOI · quote verified