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How well does CA125 find ovarian cancer in GP care?
In UK primary care, CA125 ≥35 U/ml had high NPV but only about 10% PPV for ovarian cancer, and elevated values also flagged other cancers.
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How large was the CA125-tested primary-care cohort?
50,780 women after exclusions.
Source: The diagnostic performance of CA125 for the detection of ovarian and non-ovarian cancer in primary care: A population-based cohort study · DOI · quote verified
What was the ovarian cancer incidence after CA125 testing?
0.9% overall, threefold higher in women ≥50 than <50.
Source: The diagnostic performance of CA125 for the detection of ovarian and non-ovarian cancer in primary care: A population-based cohort study · DOI · quote verified
What PPV did CA125 ≥35 U/ml achieve for ovarian cancer?
10.1% (95% CI 9.1–11.2).
Source: The diagnostic performance of CA125 for the detection of ovarian and non-ovarian cancer in primary care: A population-based cohort study · DOI · quote verified
What were sensitivity and specificity at the standard cutoff?
Sensitivity 77.0% and specificity 93.8%.
Source: The diagnostic performance of CA125 for the detection of ovarian and non-ovarian cancer in primary care: A population-based cohort study · DOI · quote verified
What AUC summarized discrimination?
AUC 0.92 overall.
Source: The diagnostic performance of CA125 for the detection of ovarian and non-ovarian cancer in primary care: A population-based cohort study · DOI · quote verified
How quickly were ovarian cancers typically diagnosed after testing?
Median 42 days from CA125 test to diagnosis.
Source: The diagnostic performance of CA125 for the detection of ovarian and non-ovarian cancer in primary care: A population-based cohort study · DOI · quote verified
What secondary cancer endpoint did authors examine?
Diagnosis of non-ovarian cancers after CA125 testing.
Source: The diagnostic performance of CA125 for the detection of ovarian and non-ovarian cancer in primary care: A population-based cohort study · DOI · quote verified
Why is CA125 used in UK primary care pathways?
NICE recommended CA125 testing for symptomatic women with possible ovarian cancer, with further investigation if elevated.
Source: The diagnostic performance of CA125 for the detection of ovarian and non-ovarian cancer in primary care: A population-based cohort study · DOI · quote verified
What NPV accompanied the ≥35 U/ml cutoff?
NPV 99.8%, meaning negatives were rarely followed by ovarian cancer in this cohort.
Source: The diagnostic performance of CA125 for the detection of ovarian and non-ovarian cancer in primary care: A population-based cohort study · DOI · quote verified
What clinical implication do the authors stress for elevated CA125?
Consider alternative cancers, especially when ovarian cancer has been excluded, particularly in women ≥50.
Source: The diagnostic performance of CA125 for the detection of ovarian and non-ovarian cancer in primary care: A population-based cohort study · DOI · quote verified
What proportion of ovarian cancers were early stage I–II?
172 of 456 (37.7%) were stage I or II.
Source: The diagnostic performance of CA125 for the detection of ovarian and non-ovarian cancer in primary care: A population-based cohort study · DOI · quote verified