How does TXNIP control muscle glucose uptake?

Human studies show TXNIP is repressed by insulin, induced by glucose, elevated in dysglycaemia, and can inhibit peripheral glucose uptake.

Keep what you just learned

Save these 11 cards to your NoteFren library. Your first review starts right away, and each card links back to the study it came from.

What physiologic role do authors assign TXNIP?

A regulator of peripheral glucose uptake in humans.

What clamp method measured insulin action?

Euglycemic hyperinsulinemic clamp.

How did insulin change TXNIP expression?

TXNIP (and BCL6) were consistently repressed by insulin.

What happens when TXNIP is elevated?

Elevations can inhibit glucose uptake.

How is TXNIP regulated by insulin vs glucose?

Reciprocally regulated by insulin and by glucose.

In which glycaemic states is TXNIP elevated?

Consistently elevated in humans with T2DM and prediabetes.

Which tissue was profiled for insulin-responsive genes?

Human skeletal muscle biopsies.

What clinical problem motivates the work?

Insulin resistance and impaired glucose uptake in type 2 diabetes.

What discovery approach found TXNIP?

Genome-wide expression profiling across clamp studies.

How does TXNIP relate to insulin-stimulated glucose metabolism?

Inversely correlated in humans, robust in NGT/IGT.

What disease epidemic frames the introduction?

Type 2 diabetes mellitus as a growing worldwide epidemic.