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Do polygenic scores work equally within one ancestry?
Even within a relatively homogeneous ancestry group, PGS prediction accuracy differs substantially across socio-economic and related strata.
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What is a polygenic score?
Sum of allele effects predicting an individual’s phenotype.
Source: Variable prediction accuracy of polygenic scores within an ancestry group · DOI · quote verified
Key finding within ancestry?
Major differences in PGS prediction accuracy among groups with highly similar genetic ancestries.
Source: Variable prediction accuracy of polygenic scores within an ancestry group · DOI · quote verified
Which cohort subset?
Large UK Biobank subset with relatively homogeneous ancestry (337,536 unrelated).
Source: Variable prediction accuracy of polygenic scores within an ancestry group · DOI · quote verified
Which characteristics were focused?
Characteristics that vary with ascertainment, including socio-economic status.
Source: Variable prediction accuracy of polygenic scores within an ancestry group · DOI · quote verified
Education example of cross-group drop?
EA3 incremental R² ~10.6% in European-Americans vs ~1.6% in African-Americans.
Source: Variable prediction accuracy of polygenic scores within an ancestry group · DOI · quote verified
Height accuracy example cited?
About 11% in UK vs 3% in Japan using European-trained scores.
Source: Variable prediction accuracy of polygenic scores within an ancestry group · DOI · quote verified
Do they further show within-group differences for many traits?
Yes—prediction accuracy differs for a variety of traits.
Source: Variable prediction accuracy of polygenic scores within an ancestry group · DOI · quote verified
Teaching point?
PGS portability fails not only across ancestries but within them.
Source: Variable prediction accuracy of polygenic scores within an ancestry group · DOI · quote verified
Best topic?
GWAS / polygenic prediction.
Source: Variable prediction accuracy of polygenic scores within an ancestry group · DOI · quote verified
Why SES strata matter?
GWAS sample ascertainment often differs by SES-related characteristics.
Source: Variable prediction accuracy of polygenic scores within an ancestry group · DOI · quote verified
Premise often assumed?
That PGS will ‘port’ well across groups similar to the GWAS sample.
Source: Variable prediction accuracy of polygenic scores within an ancestry group · DOI · quote verified