How does ZFP36 reshape metabolism after growth signals?

Growth factors induce ZFP36, which binds and decays metabolic enzyme/transporter mRNAs—especially Eno2—tuning glycolytic metabolism.

Keep what you just learned

Save these 11 cards to your NoteFren library. Your first review starts right away, and each card links back to the study it came from.

What activates ZFP36 expression and decay activity?

Acute growth factor signaling.

Which mRNA classes are bona fide ZFP36 targets?

Metabolic enzymes and nutrient transporters.

Which glycolytic enzyme is highlighted?

Enolase 2 (ENO2).

How does ZFP36 regulate Eno2?

By promoting Eno2 mRNA decay.

What in vivo developmental context is linked?

VEGF-stimulated retinal angiogenesis in neonates.

Where does ZFP36 bind Eno2?

In the 3′ UTR at AU-rich elements.

What pathway hierarchy induces ZFP36 proteins as immediate-early genes?

RTK–MAPK signaling for transcription, with mTOR contributing at the protein level.

What metabolomics change tracks elevated ENO2?

Elevated phosphoenolpyruvate (PEP) in ZFP36-family KO cells.

What broader regulatory idea does the study support?

Metabolism is controlled post-transcriptionally via mRNA stability, not only transcription/PTMs.

What method mapped direct ZFP36–mRNA contacts?

eCLIP-seq after serum stimulation.

Do ZFP36 proteins act alone among family members in the KO design?

Authors ablated ZFP36/L1/L2 together to avoid redundancy.